Settsu province (摂津国, Settsu no kuni^?) was a province of Japan, which today comprises the eastern part of Hyōgo Prefecture and the northern part of Osaka Prefecture. It was also referred to as Tsu Province (津国 Tsu no kuni), or Sesshū (摂州 Sesshū).

Osaka and Osaka Castle were the main center of the province. During the Sengoku period, the Miyoshi clan ruled Settsu and its neighbors, Izumi and Kawachi, until they were conquered by Oda Nobunaga. The provinces were ruled subsequently by Toyotomi Hideyoshi. The regents of Hideyoshi's son soon quarreled, and when Ishida Mitsunari lost the Battle of Sekigahara, the area was given to relatives of Tokugawa Ieyasu. It was from then on divided into several domains, including the Asada Domain.

The Kohama style (小浜流, Kohama-ryū^?) of sake brewing was practiced at the Kohama-juku (小浜宿^?) in the Amagasaki Domain of Settsu Province during the Edo Period.